DEG
DEG 15.2 contains 53,885 essential genes and 786 essential non-coding sequences in the following Organisms (Dec. 18, 2016).
Add the essential genes in Campylobacter jejuni NCTC 11168 and 81-176 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 166 Mandal, R. K., Jiang, T., & Kwon, Y. M. (2017). Essential genome of Campylobacter jejuni. BMC genomics, 18(1), 616. [PubMed]
Campylobacter jejuni subsp. jejuni 81-176 384

DEG 15 contains 53,038 essential genes and 786 essential non-coding sequences in the following Organisms (Dec. 7, 2017).
Update for the BLAST service.

DEG 14.7 contains 53,038 essential genes and 786 essential non-coding sequences in the following Organisms (Oct. 24, 2016).
Add the essential genes in Escherichia coli ST131 strain EC958 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Escherichia coli ST131 strain EC958 315 Phan, M.D., et al. (2013) The serum resistome of a globally disseminated multidrug resistant uropathogenic Escherichia coli clone, PLoS Genet., 9, e1003834. [PubMed]

DEG 14.6 contains 52,723 essential genes and 786 essential non-coding sequences in the following Organisms (Oct. 21, 2016).
Optimize DEG database and Fix a error in the search webpage.

DEG 14.5 contains 52,723 essential genes and 786 essential non-coding sequences in the following Organisms (Oct. 17, 2016).
Add the essential genes in Bacillus thuringiensis BMB171 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Bacillus thuringiensis BMB171 516 Bishop, A.H., Rachwal, P.A. and Vaid, A. (2014) Identification of genes required by Bacillus thuringiensis for survival in soil by transposon-directed insertion site sequencing, Curr. Microbiol., 68, 477-485. [PubMed]

DEG 14.4 contains 52,207 essential genes and 786 essential non-coding sequences in the following Organisms (Oct. 13, 2016).
Add the essential genes in human K562 cells which are essential for Oxidative Phosphorylation based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 191 Arroyo, J.D., et al. (2016) A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation, Cell Metab. [PubMed]

DEG 14.3 contains 52,016 essential genes and 786 essential non-coding sequences in the following Organisms (Sept. 28, 2016).
Add the essential genes and non-coding elements in Agrobacterium fabrum str. C58 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Brevundimonas subvibrioides ATCC 15264 412 Curtis, P.D. and Brun, Y.V. (2014) Identification of essential alphaproteobacterial genes reveals operational variability in conserved developmental and cell cycle systems, Mol. Microbiol., 93, 713-735. [PubMed]
Brevundimonas subvibrioides ATCC 15264 35 Curtis, P.D. and Brun, Y.V. (2014) Identification of essential alphaproteobacterial genes reveals operational variability in conserved developmental and cell cycle systems, Mol. Microbiol., 93, 713-735. [PubMed]

DEG 14.1 contains 51,604 essential genes and 752 essential non-coding sequences in the following Organisms (Sept. 27, 2016).
Add the essential genes and non-coding elements in Agrobacterium fabrum str. C58 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Agrobacterium fabrum str. C58 361 Curtis, P.D. and Brun, Y.V. (2014) Identification of essential alphaproteobacterial genes reveals operational variability in conserved developmental and cell cycle systems, Mol. Microbiol., 93, 713-735. [PubMed]
Agrobacterium fabrum str. C58 11 Curtis, P.D. and Brun, Y.V. (2014) Identification of essential alphaproteobacterial genes reveals operational variability in conserved developmental and cell cycle systems, Mol. Microbiol., 93, 713-735. [PubMed]

DEG 13.9 contains 51,043 essential genes and 740 essential non-coding sequences in the following Organisms (Sept. 24, 2016).
Add the essential genes and non-coding elements in Acinetobacter baumannii ATCC 17978 with Murine model of pneumonia based on the original article.
Organism (Prokaryotes) Essential genes Reference
Acinetobacter baumannii ATCC 17978 156 Wang, N., et al. (2014) Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung, MBio, 5, e01163-01114. [PubMed]
Acinetobacter baumannii ATCC 17978 1 Wang, N., et al. (2014) Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung, MBio, 5, e01163-01114. [PubMed]

DEG 13.7 contains 50,887 essential genes and 739 essential non-coding sequences in the following Organisms (Sept. 23, 2016).
Add the essential genes and non-coding elements in Acinetobacter baumannii ATCC 17978 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Acinetobacter baumannii ATCC 17978 458 Wang, N., et al. (2014) Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung, MBio, 5, e01163-01114. [PubMed]
Acinetobacter baumannii ATCC 17978 59 Wang, N., et al. (2014) Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung, MBio, 5, e01163-01114. [PubMed]

DEG 13.5 contains 50,429 essential genes and 646 essential non-coding sequences in the following Organisms (Sept. 20, 2016).
Add the essential genes in Streptococcus agalactiae A909 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Streptococcus agalactiae A909 317 Hooven, T.A. et al. The Essential Genome of Streptococcus Agalactiae.BMC Genomics, 17, 406, 2016. [PubMed]

DEG 13.4 contains 50,112 essential genes and 646 essential non-coding sequences in the following Organisms (Sept. 19, 2016).
Add the essential genes in Mus musculus based on the original article.
Organism (Eukaryotes) Essential genes Reference
Mus musculus 410 Dickinson, M.E. et al. High-throughput discovery of novel developmental phenotypes. Nature (2016). [PubMed]

DEG 13.3 contains 49,702 essential genes and 646 essential non-coding sequences in the following Organisms (Jan. 7, 2016).
Update the orignal ids for part of essential genes in the information webpage.

DEG 13.2 contains 49,702 essential genes and 646 essential non-coding sequences in the following Organisms (Jan. 6, 2016).
Add the essential genes in Rhodopseudomonas palustris CGA009 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Rhodopseudomonas palustris CGA009 522 Pechter, Kieran B., et al. "The essential genome of the metabolically versatile alphaproteobacterium Rhodopseudomonas palustris." Journal of bacteriology (2015): JB-00771. [PubMed]

DEG 13.1 contains 49,180 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 28, 2015).
Fix a error in the information webpage.

DEG 13.0contains 49,180 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 27, 2015).
Add the core essential genes in Homo sapiens in five cell-lines based on the original article.
Organism (Eukaryotes) Essential genes Type Reference
Homo sapiens 1196 A375 Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 1892 DLD1 Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 2196 GBM Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 2070 HCT116 Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 386 HCT116 by shRNA Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 1694 HeLa Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]
Homo sapiens 2038 REP1 Hart, Traver, et al. "High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities." Cell (2015).[PubMed]

DEG 12.3 contains 37,738 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 21, 2015).
Add the essential genes in Homo sapiens Raji cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 1461 Wang, Tim, et al. "Identification and characterization of essential genes in the human genome." Science 350.6264 (2015): 1096-1101. [PubMed]

DEG 12.2 contains 36,277 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 20, 2015).
Add the essential genes in Homo sapiens Jiyoye cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 1627 Wang, Tim, et al. "Identification and characterization of essential genes in the human genome." Science 350.6264 (2015): 1096-1101. [PubMed]

DEG 12.1 contains 34,650 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 19, 2015).
Add the essential genes in Homo sapiens K562 cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 1660 Wang, Tim, et al. "Identification and characterization of essential genes in the human genome." Science 350.6264 (2015): 1096-1101. [PubMed]

DEG 12.0 contains 32,990 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 18, 2015).
Add the essential genes in Homo sapiens KBM7 cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 1877 Wang, Tim, et al. "Identification and characterization of essential genes in the human genome." Science 350.6264 (2015): 1096-1101. [PubMed]

DEG 11.9 contains 31,113 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 12, 2015).
Add the essential genes in Homo sapiens HAP1 cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 2164 Blomen, Vincent A., et al. "Gene essentiality and synthetic lethality in haploid human cells." Science 350.6264 (2015): 1092-1096. [PubMed]

DEG 11.8 contains 28,949 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 11, 2015).
Add the essential genes in Homo sapiens KBM7 cells based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 2038 Blomen, Vincent A., et al. "Gene essentiality and synthetic lethality in haploid human cells." Science 350.6264 (2015): 1092-1096. [PubMed]

DEG 11.7 contains 26,911 essential genes and 646 essential non-coding sequences in the following Organisms (Dec. 3, 2015).
Add the essential genes in Homo sapiens based on the original article.
Organism (Eukaryotes) Essential genes Reference
Homo sapiens 3137 Lek, Monkol, et al. "Analysis of protein-coding genetic variation in 60,706 humans." bioRxiv (2015): 030338. [PubMed]

DEG 11.6 contains 23,774 essential genes and 680 essential non-coding sequences in the following Organisms. (Dec. 2, 2015).
Fix a error in the information webpage.

DEG 11.5 contains 23,774 essential genes and 680 essential non-coding sequences in the following Organisms (Nov. 24, 2015).
Add the essential genes and RNAs in Synechococcus elongatus PCC 7942 based on the original article.
Organism (Eukaryotes) Essential genes Reference
Synechococcus elongatus PCC 7942 682 Rubin, Benjamin E., et al. "The essential gene set of a photosynthetic organism." Proceedings of the National Academy of Sciences (2015): 201519220. [PubMed]
Synechococcus elongatus PCC 7942 34 Rubin, Benjamin E., et al. "The essential gene set of a photosynthetic organism." Proceedings of the National Academy of Sciences (2015): 201519220. [PubMed]

DEG 11.4 contains 23,092 essential genes and 646 essential non-coding sequences in the following Organisms (Nov. 23, 2015).
Fix a error in the information webpage.

DEG 11.3 contains 23,092 essential genes and 646 essential non-coding sequences in the following Organisms (Oct. 8, 2015).
Add the essential genes in Porphyromonas gingivalis ATCC 33277 based on the original article.
Organism (Eukaryotes) Essential genes Reference
Porphyromonas gingivalis ATCC 33277 281 Hutcherson, Justin A., et al (2015). Comparison of inherently essential genes of Porphyromonas gingivalis identified in two transposon sequencing libraries. Molecular Oral Microbiology. [PubMed]

DEG 11.2 contains 22,811 essential genes and 646 essential non-coding sequences (July. 3, 2015).
Fix a bug in the BLAST web server.

DEG 11.1 contains 22,811 essential genes and 646 essential non-coding sequences (May. 30, 2015).
Add the essential genes in Streptococcus pyogenes MGAS5448 and NZ131 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Streptococcus pyogenes MGAS5448 227 Le Breton Y. et al (2015). Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes. Sci. Rep. 5, 9838.[PubMed]
Streptococcus pyogenes NZ131 241

DEG 11.0 contains 22343 essential genes and 646 essential non-coding sequences (March. 21, 2015).
Add the essential genes in Pseudomonas aeruginosa PAO1 based on the original article.
Organism (Prokaryotes) Essential genes Reference
Pseudomonas aeruginosa PAO1 336 Turner, K.H., Wessel, A.K., Palmer, G.C., Murray, J.L. and Whiteley, M. (2015) Essential genome of Pseudomonas aeruginosa in cystic fibrosis sputum. Proc. Natl. Acad. Sci. U. S. A.[PubMed]

DEG 10.9 contains 22343 essential genes and 646 essential non-coding sequences in the following Organisms (Feb. 6, 2015).
Update the Uniprot ID and gene ontology annotation for the bacterial items.

DEG 10.7 contains 22343 essential genes and 646 essential non-coding sequences in the following Organisms (Jan. 13, 2015).
Update COG numbers into DEG records.

DEG 10.6 contains 22343 essential genes and 646 essential non-coding sequences in the following Organisms (Sept. 11, 2014).
Fix a bug in the BLAST webpage.

DEG 10.5 contains 22343 essential genes and 646 essential non-coding sequences in the following Organisms (Sept. 6, 2014).
Rorganize the essential genes in Danio rerio based on the original article.
Organism (Eukaryotes) Essential genes Reference
Danio rerio 315 Amsterdam A, et al (2004). Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A, 101:12792-7. [PubMed]

DEG 10.4 contains 22316 essential genes and 646 essential non-coding sequences in the following Organisms (Jul. 25, 2014).
Fix a bug to support the latest GenBank format.

DEG 10.3 contains 22316 essential genes and 646 essential non-coding sequences in the following Organisms (Jul. 24, 2014).
Organism (Prokaryotes) Essential genes Reference
Burkholderia pseudomallei K96243 505 Moule, M.G., et al. (2014) Genome-Wide Saturation Mutagenesis of Burkholderia pseudomallei K96243 Predicts Essential Genes and Novel Targets for Antimicrobial Development. MBio 5, e00926-00913 [PubMed]

DEG 10.2 contains 21811 essential genes and 646 essential non-coding sequences in the following Organisms (Jul. 12, 2014).
Update the GI numbers of Bacillus subtilis 168 and Escherichia coli MG1655 II.

DEG 10.1 contains 21811 essential genes and 646 essential non-coding sequences in the following Organisms (Jun. 6, 2014).
Organism (Prokaryotes) Essential genes Reference
Bacteroides fragilis 638R 547 Yaligara Veeranagouda, et al (2014). "Identification of genes required for the survival of B. fragilis using massive parallel sequencing of a saturated transposon mutant library". BMC Genomics, 15:429.PubMed]
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