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The Centre of Bioinformatics, Tianjin University (TUBIC) was established in 1998. Founded by Dr. Chun-Ting Zhang, the Centre is composed of a number of faculty members and graduate students, both for Master and Doctorate Degrees. TUBIC is served as a window to reveal the achievements of Bioinformatics studies in Tianjin University, China.

Chun-Ting Zhang
C.-T. Zhang is a bioinformatician. He was born in Yantai, Shandong Province, China. Zhang graduated from the Department of Physics, Fudan University in 1961 and finished his postgraduate study in the same university in 1965. Now he is a full professor of Tianjin university.

In his early years Zhang was engaged in the study of theoretical physics. Later, he shifted to the area of theoretical molecular biology. His special interest is of Bioinformatics. He established the Z curve theory of DNA sequences and developed a geometrical approach to analyze DNA sequences. The Z curve theory and related methodology have been applied to many important areas, such as computer-aided gene identification in genomes, molecular evolution and studies of long-range correlation of DNA sequences etc. He also proposed a number of new algorithms to predict the structural classes of globular proteins, increasing the prediction accuracy for given database. This work has promoted the development of structural class prediction study worldwide.

He was elected to be a Member of the Chinese Academy of Sciences in 1995, and a Fellow of the Third World Academy of Sciences (TWAS) in 2001. Zhang was awarded the Prize for Science and Technology Progress, issued by the National Education Committee in 1996 (First Class), the Prize of National Natural Science in 1997 (Second Class) and Ho Leung Ho Lee Prize for Science and Technology Progress in 2001.

Feng Gao
Dr. Gao is engaged in the bioinformatics research, which mainly focuses on microbial genomics and functional genomics. As first or corresponding author, he has published 48 peer-reviewed papers in international journals, including Nucleic Acids Research, PNAS, Briefings in Bioinformatics, Bioinformatics, and one book chapter in Gene Essentiality: Methods and Protocols, series Methods in Molecular Biology. He has developed some web-based systems, such as Ori-Finder used for finding replication origins in genomes of bacteria, archaea and budding yeast, and GC-Profile used for visualizing and analyzing the variation of GC content in genomic sequences. He also constructed some online databases, such as DoriC, a Database of oriC regions, and DEG 15, an update of Database of Essential Genes.

He obtained the Ph.D degree from Tianjin University of China in 2007 under the supervision of Prof. Chun-Ting Zhang. Then, he worked at Tianjin University as principal investigator of the Center of Bioinformatics, Tianjin University (TUBIC). In the past years, he has taken charge of four research projects funded by NSFC (National Natural Science Foundation of China) in succession. He received China Youth Science and Technology Innovation Award (2006), the nomination award for the National Excellent Doctoral Dissertation of China (2009) and was selected into the Program for New Century Excellent Talents in Universities (Chinese Ministry of Education, 2012).

Currently, he is a Faculty Member of Faculty Opinions (formerly F1000Prime) for Genomics & Genetics, the editorial board member of Briefings in Bioinformatics, Genomics, Proteomics & Bioinformatics (GPB), Scientific Reports, PLoS ONE, and serve as Associate Editor for Frontiers in Microbiology and Frontiers in Genetics. As Guest Editor, he has organized the research topic 'DNA Replication Origins in Microbial Genomes' for Frontiers in Microbiology. Given its previous success, he has been invited to launch the second volume of the topic together with Prof. Alan Leonard. Gratifyingly, the papers published in this topic series were highly accessed, and the total views are 125,000 now. He also hosted a themed issue 'Recent developments of software and database in microbial genomics and functional genomics' for Briefings in Bioinformatics as Guest Editor. The articles in this themed issue have been well-received by a wide international audience.


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