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The Centre of Bioinformatics, Tianjin University (TUBIC) was established in 2000. Headed by Dr. Chun-Ting Zhang, the Centre is composed of a number of faculty members and graduate students, both for Master and Doctorate Degrees. TUBIC is served as a window to reveal the achievements of Bioinformatics studies in Tianjin University, China.

Chun-Ting Zhang
C.-T. Zhang is a bioinformatician. He was born in Yantai, Shandong Province, China. Zhang graduated from the Department of Physics, Fudan University in 1961 and finished his postgraduate study in the same university in 1965. Now he is a full professor of Tianjin university.

In his early years Zhang was engaged in the study of theoretical physics. Later, he shifted to the area of theoretical molecular biology. His special interest is of Bioinformatics. He established the Z curve theory of DNA sequences and developed a geometrical approach to analyze DNA sequences. The Z curve theory and related methodology have been applied to many important areas, such as computer-aided gene identification in genomes, molecular evolution and studies of long-range correlation of DNA sequences etc. He also proposed a number of new algorithms to predict the structural classes of globular proteins, increasing the prediction accuracy for given database. This work has promoted the development of structural class prediction study worldwide.

He was elected to be a Member of the Chinese Academy of Sciences in 1995, and a Fellow of the Third World Academy of Sciences (TWAS) in 2001. Zhang was awarded the Prize for Science and Technology Progress, issued by the National Education Committee in 1996 (First Class), the Prize of National Natural Science in 1997 (Second Class) and Ho Leung Ho Lee Prize for Science and Technology Progress in 2001.

Feng Gao
Dr. Gao is engaged in the bioinformatics research, which mainly focuses on microbial genomics and functional genomics. As the first author or corresponding author, he has published 30 peer-reviewed papers in international journals, including PNAS, Nucleic acids research, and Bioinformatics, and one book chapter in Gene Essentiality: Methods and Protocols, series Methods in Molecular Biology. He has developed some web-based systems, such as Ori-Finder used for finding oriCs in bacterial and archaeal genomes with high accuracy, and GC-Profile used for visualizing and analyzing the variation of GC content in genomic sequences. He also constructed some online databases, such as DoriC, a database of oriC regions in both bacterial and archaeal genomes, and DeOri, a database of eukaryotic DNA replication origins.

He has received China Youth Science and Technology Innovation Award and the nomination award for the National Excellent Doctoral Dissertation of China. Furthermore, he was also supported by the Program for New Century Excellent Talents in Universities. So far, he has taken charge of four research projects on DNA replication origins funded by NSFC in succession. The predictions of bacterial replication origins have been supported by a number of experiments, including that published in Science.

Currently, Dr. Gao is a Faculty member of F1000Prime, the editorial board member of Scientific Reports, PLoS ONE, Genomics, Proteomics & Bioinformatics, and serve as Associate Editor as well as Guest Editor for Frontiers in Microbiology by organizing the research topic 'DNA Replication Origins in Microbial Genomes' and its 2nd Edition. Recently, he hosts an upcoming themed issue for Briefings in Bioinformatics as Guest Editor.


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