Welcome to TUBIC-- the Tianjin University BioInformatics Centre. Currently, TUBIC is one of the key websites for life sciences of the Ministry of Education, China. This Bioinformatics center offers a number of services based on Bioinformatics softwares developed at TUBIC during the past few years. These softwares include those for gene-finding in the yeast genome ZCURVE_Y, ab initio gene-recognition ZCURVE_B and replication origin prediction Ori-Finder and Ori-Finder 2 in bacterial and archaeal genomes, gene-identification for virus genomes, and especially for coronavirus genomes. Additionally, TUBIC also hosts four databases: the Z-curve databaseZcurve_DB, displaying the Z-curves for more than 1000 genomes, the Database of Essential Genes (DEG) for microbial genomes, the database of replication origins in bacterial genomes (DoriC), and the database listing potential G-quadruplex regulated genes Greglist. Now TUBIC serves as one of the windows to display the achievements of Bioinformatics research in China. TUBIC.ORG is the mirror site of TUBIC.

Special issue on Z-curve applications in genome analysis
Editorial (Thematic Issue: Z-curve Applications in Genome Analysis)
A brief review: the Z-curve theory and its application in genome analysis
Recognition of protein-coding genes based on Z-curve algorithms
Recent advances in the identification of replication origins based on the Z-curve method
Identification of horizontally-transferred genomic islands and genome segmentation points by using the GC profile method

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  Resource at TUBIC  





ZCURVE 3.0 Ori-Finder 2 Ori-Finder, GC-Profile, ZCURVE_CoV 2.0, ZCURVE 2.0 and other gene finding programs.


ZCURVE-CoV database, DoriC 5.0, DEG 15.2,
The Z curve Database of Genomes 3.0, DeOri 6.0 pDEG Greglist 2.0.



Selected papers published during recent years




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